Potassium Carbonate → HCID 15379667, compound

HRID 397330Notes

Reaction equation

[C:1]([O:4][CH2:5][CH2:6][O:7][C:8]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH:9]([OH:14])[C:10]([O:12][CH3:13])=[O:11])(=[O:3])[CH3:2].C([O-])([O-])=O.[K+].[K+].CS([C:37]1[N:42]=[C:41]([O:43][CH3:44])[CH:40]=[C:39]([CH3:45])[N:38]=1)(=O)=O>CN(C=O)C.O>[C:1]([O:4][CH2:5][CH2:6][O:7][C:8]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH:9]([O:14][C:37]1[N:42]=[C:41]([O:43][CH3:44])[CH:40]=[C:39]([CH3:45])[N:38]=1)[C:10]([O:12][CH3:13])=[O:11])(=[O:3])[CH3:2]

Participants

Conditions

Temperature: 80 °C

Procedure

4 g (11.1 mmol) of methyl 3-(2-acetoxyethoxy)-2-hydroxy-3,3-di-phenylpropionate were dissolved in 20 ml of DMF under N2, 770 mg (5.6 mmol) of K2CO3 and 2.24 g (11.1 mmol) of 2-methanesulfonyl-4-methoxy-6-methylpyrimidine were added, and the mixture was stirred at 80° C. for 2 h. It was subsequently diluted with 20 ml of H2O and extracted twice with 30 ml of diethyl ether, the organic phase was dried over MgSO4 and concentrated, and the residue was purified by chromatography on silica gel with ethyl acetate/cyclohexane mixtures. 4.8 g (90%) of a colorless oil were obtained.

Workup

extractionextracted twice with 30 ml of diethyl ether
dry with materialthe organic phase was dried over MgSO4
concentrationconcentrated
customthe residue was purified by chromatography on silica gel with ethyl acetate/cyclohexane mixtures

Sources & evidence

ORD record: ord-03b1439572b6444597f8fdae9cae1202
Source dataset: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06610691B1

Reaction notes

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