反应详情

温度

100 °C

To 20 mL of an N,N-dimethylformamide solution containing 2.25 g of methyl gallate, 1.3 mL of 1,2-dibromoethane and 4.05 g of potassium carbonate were added, and the mixture was stirred at 100° C. overnight. The reaction mixture was cooled to room temperature, then fed into water, and the resultant solution was extracted with a mixed solvent of ethyl acetate:toluene of 5:1. The organic layer was washed with water and an aqueous saturated sodium chloride solution, and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to obtain 1.66 g of a brown oily substance, methyl 8-hydroxy-2,3-dihydro-1,4-benzodioxin-6-carboxylate.

1. additionwere added
2. temperatureThe reaction mixture was cooled to room temperature
3. extractionthe resultant solution was extracted with a mixed solvent of ethyl acetate
4. washThe organic layer was washed with water
5. dry with materialan aqueous saturated sodium chloride solution, and dried over anhydrous magnesium sulfate
6. customthe solvent was removed under reduced pressure