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HRID3978

反应详情

EQUATION

反应方程式

HRID 3978 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：COc1ccc2cc([C@H](C)C(=O)O)ccc2c1
HCID156391

Naproxen

C14H14O3

PRODUCTS

生成物

1
结构：COc1ccc2cc([C@H](C)C(=O)OCC(C)C)ccc2c1
HCID54469957

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)CO
溶剂HCID6560

2-Methyl-1-propanol

C4H10O

PROCEDURE

实验过程

A solution of 300 mg of (S)-2-(6-methoxy-2-naphthyl)propionic acid in 5 ml of isobutyl alcohol is saturated with hydrogen chloride. After 24 hours, the excess alcohol is distilled off in vacuo and the residue is purified by chromatography using an alumina substrate to yield isobutyl (S)-2-(6-methoxy-2-naphthyl)propionate.

WORKUP

后处理

  1. distillationthe excess alcohol is distilled off in vacuo
  2. customthe residue is purified by chromatography