Hydrochloric Acid → HCID 9939091, compound

HRID 397974Notes

Reaction equation

HRID 397974 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:13]([C:14](=[O:31])[NH:15][CH2:16][CH2:17][CH:18]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[C:12]([CH2:32][O:33][CH2:34][CH2:35][CH:36]3[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]3)[NH:11][C:10]([CH3:42])=[C:9]2[C:43]([O:45]CCC#N)=[O:44])[CH:5]=[CH:6][CH:7]=1.[OH-].[Na+].Cl.O>CO>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:13]([C:14](=[O:31])[NH:15][CH2:16][CH2:17][CH:18]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)=[C:12]([CH2:32][O:33][CH2:34][CH2:35][CH:36]3[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]3)[NH:11][C:10]([CH3:42])=[C:9]2[C:43]([OH:45])=[O:44])[CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 9831339HCID 9831339, compound

Product 1

HCID 9939091HCID 9939091, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.25 g (0.37 mmol) of 2-cyanoethyl 4-(3-chlorophenyl)-6-(2-cyclohexylethoxymethyl)-5-(3,3-diphenylpropylcarbamoyl)-2-methyl-1,4-dihydropyridine-3-carboxylate was dissolved in 5 ml of methanol. 0.73 ml of 1 N aqueous sodium hydroxide solution was added to the obtained solution, and they were stirred at room temperature for 2 hours. 1 N hydrochloric acid and water were added to the reaction mixture. The precipitates thus formed were taken by the filtration and dried under reduced pressure to obtain the title compound.

Workup

  1. customThe precipitates thus
  2. customformed
  3. filtrationwere taken by the filtration
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-487955a6ab7f49778aea24d446ee5bfa
Source dataset
uspto-grants-2003_08
Patent number
US06610717B2

Reaction notes

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