Hydrogen Bromide → HCID 23001313, compound

HRID 398005Notes

Reaction equation

HRID 398005 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([S:9]([CH2:12][CH2:13][CH2:14][N:15]2C(=O)C3C(=CC=CC=3)C2=O)(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1.[BrH:26]>C(O)(=O)C>[BrH:26].[NH2:15][CH2:14][CH2:13][CH2:12][S:9]([C:5]1[CH:4]=[C:3]([OH:2])[CH:8]=[CH:7][CH:6]=1)(=[O:10])=[O:11]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 23001317HCID 23001317, compound

Product 1

HCID 23001313HCID 23001313, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The sulfone from Step B (1.32 g, 3.67 mmol) in acetic acid (2 mL) and 48% HBr (2 mL) was heated at 100° C. for 72 hours. The reaction mixture was concentrated and the solid residue triturated with ether (200 mL) to produce the title compound as a grey solid.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe solid residue triturated with ether (200 mL)

Sources & evidence

ORD record
ord-6ca11fc85591452290b38b991ee8bf0f
Source dataset
uspto-grants-2003_08
Patent number
US06610722B2

Reaction notes

Loading…