Sodium Bisulfate → HCID 23002371, compound

HRID 398251Notes

Reaction equation

HRID 398251 reaction equation
N[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([N:11]([CH3:14])[O:12][CH3:13])(=[O:10])=[O:9].[N:15]([O-])=O.[Na+].[S:19]([O-:23])(O)(=O)=[O:20].[Na+]>>[CH3:14][N:11]([S:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[S:19]([NH2:15])(=[O:23])=[O:20])(=[O:10])=[O:9])[O:12][CH3:13]

Participants

4

Reactant 3

HCID 516919Sodium BisulfateHCID 23668193Sodium NitriteHCID 43627497HCID 43627497, compound2×

Product 1

HCID 23002371HCID 23002371, compoundYield 1,174.2%

Procedure

2-amino-N-methyl-N-methoxyphenylsulfonamide [Xn=2-SO2N(OCH3)CH3 in Compound (XXV)] (5.4 g, 25 mmol) was diazotized with sodium nitrite (2.07 g, 25×1.2 mmol) and the resultant diazonium compound was allowed to react with sodium hydrogen sulfate (7.28 g, 25×2.8 mmol) to obtain 3.95 g (percent yield: 56.37%) of 2-[(N-methyl-N-methoxyamino)sulfonyl] phenylsulfonamide [Compound (III-18)].

Sources & evidence

ORD record
ord-75e04276fac44a27a2454d2726e5ff4a
Source dataset
uspto-grants-2003_08
Patent number
US06610853B1

Reaction notes

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