Dimethylformamide → HCID 66929778, compound
Reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.CN([CH:10]=[O:11])C>>[NH2:1][C@@H:6]([CH:5]1[CH2:6][C:5]2[C:3](=[CH:2][CH:2]=[CH:3][CH:4]=2)[CH2:4]1)[CH2:10][OH:11]Participants
3
Conditions
- Temperature
- 25 °C
Procedure
20% Piperidine in DMF (15 mL) was added to a solution of 9 H-fluoren-9-ylmethyl-(1S)-1-(2,3-dihydro-1H-inden-2-yl)-2-hydroxyethylcarbamate (1.05 g, 2.63 mmol) in DMF (5 mL). The reaction was stirred at 25° C. for 19 h. After solvent evaporation, the crude product was dissolved in ethyl acetate (50 mL) and dried over MgSO4, filtered and concentrated to obtain a crude yellow oil (1.05 g). Mass Spectrum (+ESI): 179 (M+H)+.
Workup
- customAfter solvent evaporation
- dissolutionthe crude product was dissolved in ethyl acetate (50 mL)
- dry with materialdried over MgSO4
- filtrationfiltered
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-1ffdbe62e7554277833aabc06b28eb4f
- Source dataset
- uspto-grants-2003_08
- Patent number
- US06610734B2
Reaction notes
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