反应详情

2.1 g of 2-[(N-Boc)amino]-3-(4-cyanophenyl)-propionic acid are mixed with 0.715 g of 2,5-dimethyl-2,5-dihydropyrrole in 10 ml of DMF, 3.9 g of BOP are added and the pH is adjusted to 7 by addition of Et3N. After stirring for 18 hours at RT, the mixture is evaporated to dryness and is then taken up in EtOAc, washed with NaHCO3 solution, with KHSO4/K2SO4 and with saturated NaCl solution. The resulting solution is dried over Na2SO4 and then evaporated. The residue is taken up in an ether/hexane mixture and then dried over Na2SO4. 1.4 g of the expected compound are obtained.

1. additionare added
2. customthe mixture is evaporated to dryness
3. washwashed with NaHCO3 solution, with KHSO4/K2SO4 and with saturated NaCl solution
4. dry with materialThe resulting solution is dried over Na2SO4
5. customevaporated
6. dry with materialdried over Na2SO4