反应详情

A solution of phosphorus oxybromide (14.4 g, 50 mmol) in 1,2-dichloroethane (50 mL) was added to a stirred suspension of 2-hydroxy-4-methyl-5-nitropyridine (5 g, 32.4 mmol) in 1,2-dichloroethane (50 mL) and the resulting mixture was heated to reflux. After 4 h, the reaction was cooled and quenched with water. The organic layer was dried (Na2SO4), filtered through a pad of silica eluting with chloroform and evaporated in vacuo to give the title compound as a yellow solid:

1. temperaturethe resulting mixture was heated to reflux
2. temperaturethe reaction was cooled
3. customquenched with water
4. dry with materialThe organic layer was dried (Na2SO4)
5. filtrationfiltered through a pad of silica eluting with chloroform
6. customevaporated in vacuo