2,2-Difluoro-2-(2-pyridyl)ethylazide → 2,2-Difluoro-2-pyridin-2-ylethaneamine

HRID 398365Notes

Reaction equation

HRID 398365 reaction equation
[F:1][C:2]([F:13])([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)[CH2:3][N:4]=[N+]=[N-]>C(OCC)(=O)C.[Pd]>[F:13][C:2]([F:1])([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)[CH2:3][NH2:4]

Participants

4

Reactant 1

HCID 118054052,2-Difluoro-2-(2-pyridyl)ethylazide

Product 1

HCID 99641672,2-Difluoro-2-pyridin-2-ylethaneamine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A stirred solution of 100 mg of 2,2-difluoro-2-(2-pyridyl)ethylazide was hydrogenated in 10 mL of ethyl acetate over 100 mg of 10% palladium on carbon using a balloon for 1 h. The catalyst was removed by filtration and the solvents removed at reduced pressure to give the title compound as a yellow oil:

Workup

  1. customfor 1 h
  2. customThe catalyst was removed by filtration
  3. customthe solvents removed at reduced pressure

Sources & evidence

ORD record
ord-d44c3debdee54d528ae653270d56a3de
Source dataset
uspto-grants-2003_08
Patent number
US06610692B1

Reaction notes

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