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HRID3986

反应详情

EQUATION

反应方程式

HRID 3986 的结构方程式

REACTANTS

反应物

3
结构：CS(=O)(=O)O
HCID6395

Methanesulfonic acid

CH4O3S

结构：C=C(C)OC(C)=O
HCID7916

Isopropenyl acetate

C5H8O2

结构：CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3C=CC4=CC(=O)C=C[C@]4(C)[C@H]3CC[C@]12C
HCID107390

Cholesta-1,4,6-trien-3-one

C27H40O

PRODUCTS

生成物

1
结构：CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2C3=CC=C4CC(O)C=C[C@]4(C)[C@H]3CC[C@]12C
HCID18611553

未命名化合物

收率 61.2%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

To a mixture of 19 g (0.05 mol) of cholesta-1,4,6-trien-3-one (I), 4.8 g (0.05 mol) of methanesulfonic acid and 200 g (2 mol) of isopropenyl acetate were added 200 ml of toluene, and the resulting mixture was then heated under reflux for 6 hours. After completion of the reaction, the same treatment as in Example 1 was carried out to yield 11.7 g of cholesta-1,5,7-trien-3-ol (IV). The yield was 61%.

WORKUP

后处理

  1. temperaturethe resulting mixture was then heated
  2. temperatureunder reflux for 6 hours
  3. customAfter completion of the reaction