Hydrazine hydrate (1:1) → HCID 18183948, compound

HRID 398756Notes

Reaction equation

HRID 398756 reaction equation
[CH2:1]([S:23][CH2:24][CH2:25][C:26]([O:28]CC)=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22].O.[NH2:32][NH2:33]>C(O)CC>[CH2:1]([S:23][CH2:24][CH2:25][C:26]([NH:32][NH2:33])=[O:28])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21260124HCID 21260124, compound

Product 1

HCID 18183948HCID 18183948, compound

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

22.1 Grams of ethyl 3-(docosylthio)propionate, 150 ml of n-propanol and 12.5 g of hydrazine monohydrate were charged in a flask equipped with a stirrer, a condenser and a calcium chloride drying tube and refluxed with heating for 20 hours. The reaction mixture was cooled to room temperature and the precipitated crystal was filtered off under reduced pressure and washed with distilled water. The crystal was recrystallized from 2-propanol to obtain 17.2 g of the desired product. m.p. 106° C.

Workup

  1. customequipped with a stirrer, a condenser and a calcium chloride drying tube
  2. temperaturerefluxed
  3. temperaturewith heating for 20 hours
  4. filtrationthe precipitated crystal was filtered off under reduced pressure
  5. washwashed with distilled water
  6. customThe crystal was recrystallized from 2-propanol

Sources & evidence

ORD record
ord-34d91484bf844277bfa40f188efc47b9
Source dataset
uspto-grants-1998_10
Patent number
US05817599

Reaction notes

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