Potassium Carbonate → HCID 86591753, compound

HRID 398772Notes

Reaction equation

HRID 398772 reaction equation
[CH2:1]([O:3][P:4]([CH2:9][O:10][CH2:11]/[CH:12]=[CH:13]\[CH2:14]Cl)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2].[Cl:16][C:17]1[N:25]=[C:24]([NH2:26])[N:23]=[C:22]2[C:18]=1[NH:19][CH:20]=[N:21]2.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:6]([O:5][P:4]([CH2:9][O:10][CH2:11]/[CH:12]=[CH:13]\[CH2:14][N:21]1[CH:20]=[N:19][C:18]2[C:22]1=[N:23][C:24]([NH2:26])=[N:25][C:17]=2[Cl:16])([O:3][CH2:1][CH3:2])=[O:8])[CH3:7]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 53603492-Amino-6-chloropurineHCID 86587036HCID 86587036, compound

Product 1

HCID 86591753HCID 86591753, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
20 °C

Procedure

A mixture of Z-(4-chloro-2-butenyloxy)methyl phosphonic acid diethylester (1.05 g, 4 mmol), 6-chloro-2-aminopurine (1 g, 6 mmol) and potassium carbonate (0.92 g, 6 mmol) in anhydrous dimethylformamide (10 ml) is stirred 2 days at 20° C. The reaction mixture is concentrated in vacuo and the residue is purified by flash chromatography on silica gel to give the title product (0.85 g, 55%).

Workup

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. customthe residue is purified by flash chromatography on silica gel

Sources & evidence

ORD record
ord-7339e2d98a234b0887bc4fd05a4fcdb5
Source dataset
uspto-grants-1998_10
Patent number
US05817647

Reaction notes

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