Potassium Carbonate → HCID 53795299, compound

HRID 398774Notes

Reaction equation

[CH2:1]([O:3][P:4]([CH2:9][O:10][CH2:11][C:12]#[C:13][CH2:14]Cl)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2].[Cl:16][C:17]1[N:25]=[C:24]([NH2:26])[N:23]=[C:22]2[C:18]=1[NH:19][CH:20]=[N:21]2.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:6]([O:5][P:4]([CH2:9][O:10][CH2:11][C:12]#[C:13][CH2:14][N:21]1[CH:20]=[N:19][C:18]2[C:22]1=[N:23][C:24]([NH2:26])=[N:25][C:17]=2[Cl:16])([O:3][CH2:1][CH3:2])=[O:8])[CH3:7]

Participants

Conditions

Temperature: 20 °C

Procedure

A mixture of (4-chloro-2-butynyloxy)methylphosphonic acid diethylester (2.03 g, 8 mmol), 6-chloro-2-aminopurine (2 g, 12 mmol) and potassium carbonate (1.85 g, 12 mmol) in anhydrous dimethylformamide (15 ml) is stirred 2 days at 20° C. under argon. The reaction mixture is concentrated in vacuo, and the residue is purified by flash chromatography on silica gel to give the title product (1.7 g, 65%).

Workup

concentrationThe reaction mixture is concentrated in vacuo
customthe residue is purified by flash chromatography on silica gel

Sources & evidence

ORD record: ord-145f699df6de4d1fb76e04172fcf55b4
Source dataset: uspto-grants-1998_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05817647

Reaction notes

Loading…