Triethylamine → HCID 18393861, compound

HRID 399171Notes

Reaction equation

HRID 399171 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][CH:9](N)[CH3:10])[CH:5]=[CH:6][CH:7]=1.C(O[C:15](=[O:23])[C@@:16](S(C)(=O)=O)([CH3:18])O)C.C([N:26](CC)CC)C>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:9][CH2:10][NH:26][C@H:16]([CH3:18])[C:15]2=[O:23])[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 21835122HCID 21835122, compoundHCID 86753201HCID 86753201, compound

Product 1

HCID 18393861HCID 18393861, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 18.4 g (0.108 moles) of N-(3-chlorophenyl)-ethanediamine (J. Med. Chem., 9, 858-860 (1966)), 19.3 ml (0.119 moles) of (S)-methanesulfonyl-lactic acid ethyl ester and 22.8 ml (0.163 moles) of triethylamine in 200 ml of toluene was boiled and refluxed overnight.

Workup

  1. temperaturerefluxed overnight

Sources & evidence

ORD record
ord-7a973375b9d645b48d650671ec42d041
Source dataset
uspto-grants-1998_10
Patent number
US05817815

Reaction notes

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