Morpholine → HCID 178507838, compound

HRID 399561Notes

Reaction equation

HRID 399561 reaction equation
[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([NH:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([C:27](O)=[O:28])[CH2:23][CH2:22]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)=[CH:4][C:3]=1[Cl:30].F[B-](F)(F)F.N1(OC(N(C)C)=[N+](C)C)C2C=CC=CC=2N=N1.[NH:53]1[CH2:58][CH2:57][O:56][CH2:55][CH2:54]1>C(N(CC)CC)C>[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([NH:20][C@H:21]4[CH2:22][CH2:23][C@H:24]([C:27]([N:53]5[CH2:58][CH2:57][O:56][CH2:55][CH2:54]5)=[O:28])[CH2:25][CH2:26]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)=[CH:4][C:3]=1[Cl:30]

Participants

5

Reactant 3

HCID 8083MorpholineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 178507839HCID 178507839, compound

Product 1

HCID 178507838HCID 178507838, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Prepared from 4-[(4-amino-3,5-dichlorophenyl)amino]-6-[(trans-4-carboxycyclohexyl)amino]pyrimido[5,4-d]pyrimidine by reaction with O-(benzotriazol-1-yl)-N,N,N',N',-tetramethyluronium tetrafluoroborate, triethylamine and morpholine. Melting point: 204°-207° C.; Rf : 0.53 (silica gel; petroleum ether/ethyl acetate/methanol=10:10:4)

Sources & evidence

ORD record
ord-29392faa374b4240956aa3c28c14ea95
Source dataset
uspto-grants-1998_10
Patent number
US05821240

Reaction notes

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