Formaldehyde → HCID 18967328, compound

HRID 399565Notes

Reaction equation

HRID 399565 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([N:20]4[CH2:25][CH2:24][CH:23]([CH:26]5[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]5)[CH2:22][CH2:21]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8].C=O.[C:34]([BH3-])#N.[Na+]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([N:20]4[CH2:25][CH2:24][CH:23]([CH:26]5[CH2:31][CH2:30][N:29]([CH3:34])[CH2:28][CH2:27]5)[CH2:22][CH2:21]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 5003444Sodium cyanoborohydrideHCID 18946128HCID 18946128, compound

Product 1

HCID 18967328HCID 18967328, compound

Procedure

Prepared from 4-[(3-chloro-4-fluorophenyl)amino]-6-[4-(4-piperidinyl)-1-piperidinyl]pyrimido[5,4-d]pyrimidine by reductive amination with formaldehyde and sodium cyanoborohydride. Melting point: 159°-162° C.; Rf : 0.58 (alumina; petroleum ether/ethyl acetate/methanol=10:10:1)

Sources & evidence

ORD record
ord-afd63b7bb49349eab58a4cb7096eee84
Source dataset
uspto-grants-1998_10
Patent number
US05821240

Reaction notes

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