Trifluoroacetic acid → HCID 18946229, compound

HRID 399566Notes

Reaction equation

HRID 399566 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([NH:20][CH:21]4[CH2:26][CH2:25][N:24]([C:27](OC(C)(C)C)=O)[CH2:23][CH2:22]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8].FC(F)(F)C(O)=O.[N:41]#CBr>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([NH:20][CH:21]4[CH2:26][CH2:25][N:24]([C:27]#[N:41])[CH2:23][CH2:22]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 10476Cyanogen BromideHCID 18967316HCID 18967316, compound

Product 1

HCID 18946229HCID 18946229, compound

Procedure

Prepared from 4-[(3-chloro-4-fluorophenyl)amino]-6-[1-tert-butyloxycarbonyl-4-piperidinylamino]pyrimido[5,4-d]pyrimidine by reaction with trifluoroacetic acid and subsequent reaction with cyanogen bromide. Melting point: 245°-247° C.; Rf : 0.59 (silica gel; petroleum ether/ethyl acetate/methanol=10:10:3)

Sources & evidence

ORD record
ord-bf7dfb838ba546d6a84664e7c36fc25d
Source dataset
uspto-grants-1998_10
Patent number
US05821240

Reaction notes

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