Methanesulfonyl chloride → HCID 18967420, compound

HRID 399574Notes

Reaction equation

HRID 399574 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([N:20]4[CH2:25][CH2:24][CH:23]([NH:26][CH3:27])[CH2:22][CH2:21]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8].[CH3:28][S:29](Cl)(=[O:31])=[O:30]>C(N(CC)CC)C>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([N:20]4[CH2:21][CH2:22][CH:23]([N:26]([CH3:27])[S:29]([CH3:28])(=[O:31])=[O:30])[CH2:24][CH2:25]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 18967290HCID 18967290, compound

Product 1

HCID 18967420HCID 18967420, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Prepared from Compound 153 in Example 1 by reaction with methanesulphonyl chloride and triethylamine. Melting point: 225°-227° C.; Rf : 0.53 (alumina; petroleum ether/ethyl acetate/methanol=10:10:1); Calculated: C 48.97 H 4.54 N 21.04; Found: 49.07 4.59 20.75

Sources & evidence

ORD record
ord-4db20fec0bfa4a0bad728fcc7e35f418
Source dataset
uspto-grants-1998_10
Patent number
US05821240

Reaction notes

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