Glyceryl Monobehenate → Clavulanic Acid

HRID 399690Notes

Reaction equation

[CH2:1]1[C:4](=[O:5])[N:3]2[C@@H:6]([C:12]([O-:14])=[O:13])/[C:7](/[O:11][C@H:2]12)=[CH:8]/[CH2:9][OH:10].[K+].C(OCC(CO)O)(=O)CCCCCCCCCCCCCCCCCCCCC>>[CH2:1]1[C:4](=[O:5])[N:3]2[C@@H:6]([C:12]([OH:14])=[O:13])/[C:7](/[O:11][C@H:2]12)=[CH:8]/[CH2:9][OH:10]

Participants

Reactant 2

HCID 5362585Glyceryl Monobehenate

HCID 23665591Potassium Clavulanate

Product 1

HCID 5280980Clavulanic Acid

Procedure

148.8 mg of potassium clavulanate was blended with 141.2 mg of glyceryl behenate in a Hobart blender (batchsize: 7 kgs), and the blend thus obtained was granulated as described above, to obtain Clavulanate compression mix Formula B2.

Workup

customthe blend thus obtained

Sources & evidence

ORD record: ord-f0e7fcbf33be46a695bc8877e2efc9ab
Source dataset: uspto-grants-1998_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05824344

Reaction notes

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