HCID 54158441, compound → HCID 54416739, compound

HRID 399722Notes

Reaction equation

HRID 399722 reaction equation
[OH:1][C:2]([P:18](=[O:21])([OH:20])[OH:19])([P:14](=[O:17])([OH:16])[OH:15])[CH2:3][CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][CH:5]1[S:10]C(=O)C>Cl.O>[OH:1][C:2]([P:14](=[O:15])([OH:16])[OH:17])([P:18](=[O:19])([OH:20])[OH:21])[CH2:3][CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][CH:5]1[SH:10]

Participants

4

Reactant 1

HCID 54158441HCID 54158441, compound

Product 1

HCID 54416739HCID 54416739, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Procedure

[1-Hydroxy-2-(2-(acetylthio)cyclohexyl)ethylidene]bis[phosphonic acid] is heated at reflux in concentrated hydrochloric acid for 7 hours. The reaction is concentrated under reduced pressure and the solid residue is triturated in ethanol. The product is obtained by recrystallization the crude solid in ethanol and water.

Workup

  1. concentrationThe reaction is concentrated under reduced pressure
  2. customthe solid residue is triturated in ethanol
  3. customThe product is obtained by recrystallization the crude solid in ethanol

Sources & evidence

ORD record
ord-a87cb3130d934237aad5fdd6538aa0ad
Source dataset
uspto-grants-1998_10
Patent number
US05824661

Reaction notes

Loading…