Diisopropyl Ether → HCID 18945281, compound

HRID 399867Notes

Reaction equation

HRID 399867 reaction equation
[ClH:1].O1CCOCC1.[N:8]1([C:13]2[CH:14]=[C:15]([CH:22]=[CH:23][CH:24]=2)[C:16]([N:18]=[C:19]([NH2:21])[NH2:20])=[O:17])[CH:12]=[N:11][N:10]=[N:9]1.C(OC(C)C)(C)C>CO>[ClH:1].[N:8]1([C:13]2[CH:14]=[C:15]([CH:22]=[CH:23][CH:24]=2)[C:16]([N:18]=[C:19]([NH2:21])[NH2:20])=[O:17])[CH:12]=[N:11][N:10]=[N:9]1

Participants

5

Reactant 3

HCID 7914Diisopropyl EtherHCID 18945200HCID 18945200, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 18945281HCID 18945281, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4N-Hydrogen chloride-dioxane (3.0 ml) was added to a mixture of 2-[3-(1H-tetrazol-1-yl)benzoyl]guanidine (1.4 g) in methanol (30 ml) and the mixture was stirred for 1 hour at ambient temperature. To the mixture was added diisopropyl ether (30 ml) and the precipitate was collected by filtration. The precipitate was recrystallized from methanol to give 2-[3-(1H-tetrazol-1-yl)benzoyl]guanidine hydrochloride (1.05 g).

Workup

  1. filtrationthe precipitate was collected by filtration
  2. customThe precipitate was recrystallized from methanol

Sources & evidence

ORD record
ord-a1bcb8c321ae4107938920d3575ed211
Source dataset
uspto-grants-1998_10
Patent number
US05824691

Reaction notes

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