Methanesulfonic Acid → HCID 86753234, compound

HRID 399873Notes

Reaction equation

HRID 399873 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[C:6]([C:8]1[N:9]([C:13]2[CH:14]=[C:15]([CH:22]=[C:23]([C:25]([N:27]=[C:28]([NH2:30])[NH2:29])=[O:26])[CH:24]=2)[C:16]([N:18]=[C:19]([NH2:21])[NH2:20])=[O:17])[CH:10]=[CH:11][CH:12]=1)#[N:7]>CO>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[C:6]([C:8]1[N:9]([C:13]2[CH:24]=[C:23]([CH:22]=[C:15]([C:16]([N:18]=[C:19]([NH2:21])[NH2:20])=[O:17])[CH:14]=2)[C:25]([N:27]=[C:28]([NH2:29])[NH2:30])=[O:26])[CH:10]=[CH:11][CH:12]=1)#[N:7]

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 18945260HCID 18945260, compound

Product 1

HCID 86753234HCID 86753234, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methanesulfonic acid (0.5 ml) was added to a solution of 2-[3-(2-cyanopyrrol-1-yl)-5-(diaminomethyleneaminocarbonyl) benzoyl]guanidine (0.8 g) in methanol (16 ml) and the whole was stirred for 1 hour at ambient temperature. The isolated precipitate was collected by filtration and recrystallized from water to give 2-[3-(2-cyanopyrrol-1-yl) -5-(diaminomethyleneaminocarbonyl)benzoyl]guanidine dimethanesulfonate (0.65 g).

Workup

  1. filtrationThe isolated precipitate was collected by filtration
  2. customrecrystallized from water

Sources & evidence

ORD record
ord-9e01f88bfde249f1833d15a2fd301cbc
Source dataset
uspto-grants-1998_10
Patent number
US05824691

Reaction notes

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