Methanesulfonic Acid → 2-[3-(2-Cyanopyrrol-1-yl)benzoyl]guanidine methanesulfonate

HRID 399878Notes

Reaction equation

HRID 399878 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[C:6]([C:8]1[N:9]([C:13]2[CH:14]=[C:15]([CH:22]=[CH:23][CH:24]=2)[C:16]([N:18]=[C:19]([NH2:21])[NH2:20])=[O:17])[CH:10]=[CH:11][CH:12]=1)#[N:7].C(OCC)(=O)C>CO>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[C:6]([C:8]1[N:9]([C:13]2[CH:14]=[C:15]([CH:22]=[CH:23][CH:24]=2)[C:16]([N:18]=[C:19]([NH2:20])[NH2:21])=[O:17])[CH:10]=[CH:11][CH:12]=1)#[N:7]

Participants

5

Reactant 3

HCID 6395Methanesulfonic AcidHCID 8857Ethyl AcetateHCID 189451892-[3-(2-Cyanopyrrol-1-yl)benzoyl]guanidine

Product 1

HCID 867532352-[3-(2-Cyanopyrrol-1-yl)benzoyl]guanidine methanesulfonate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methanesulfonic acid (0.8 ml) was added to a mixture of 2-[3-(2-cyanopyrrol-1-yl)benzoyl]guanidine (2.0 g) in methanol (20 ml) and the mixture was stirred for 30 minutes at ambient temperature. To the mixture was added ethyl acetate (20 ml) and isolated precipitate was collected by filtration. The precipitate was recrystallized from water to give 2-[3-(2-cyanopyrrol-1-yl)benzoyl]guanidine methanesulfonate (1.48 g).

Workup

  1. customisolated precipitate
  2. filtrationwas collected by filtration
  3. customThe precipitate was recrystallized from water

Sources & evidence

ORD record
ord-4f19722ec46d44dcba0ab3ec1beba662
Source dataset
uspto-grants-1998_10
Patent number
US05824691

Reaction notes

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