反应详情

176 g of ethyl cinnamate, 108 g of phenylhydrazine, 200 ml of a 28% methanol solution of sodium methoxide and 400 ml of acetonitrile were mixed and heated under reflux for 1 hour in a nitrogen stream. The reaction solution was poured into 2 l of water and 100 ml of hydrochloric acid was added thereto to produce precipitate. The precipitate was collected by filtration and recrystallized from acetonitrile to obtain 180 g of 1-phenyl-5-phenylpyrazolidin-3-one (A) as white crystals. ##STR14## Synthesis of Compound (B):

1. temperatureheated
2. temperatureunder reflux for 1 hour in a nitrogen stream
3. additionwas added
4. customto produce precipitate
5. filtrationThe precipitate was collected by filtration
6. customrecrystallized from acetonitrile