Phosphorus oxychloride → 2-Chloro-6,7,8,9-tetrahydro-7-(phenylmethyl)-5H-pyrido[2,3-D]azepine

HRID 400105Notes

Reaction equation

HRID 400105 reaction equation
Cl.Cl.O[C:4]1[CH:5]=[CH:6][C:7]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:10][CH2:9][C:8]=2[N:21]=1.P(Cl)(Cl)([Cl:24])=O>>[Cl:24][C:4]1[CH:5]=[CH:6][C:7]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:10][CH2:9][C:8]=2[N:21]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178478868HCID 178478868, compound

Product 1

HCID 189434032-Chloro-6,7,8,9-tetrahydro-7-(phenylmethyl)-5H-pyrido[2,3-D]azepine

Procedure

Prepared by reacting 2-hydroxy-7-benzyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine dihydrochloride with phosphorus oxychloride at 140° C.

Workup

  1. customPrepared
  2. customat 140° C.

Sources & evidence

ORD record
ord-26998b13408a4e338091365c1ee5a122
Source dataset
uspto-grants-1998_10
Patent number
US05827849

Reaction notes

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