Phosphorus oxychloride → 3-Chloro-7-ethyl-6,7,8,9-tetrahydro-5H-pyrido[3,4-d]azepine

HRID 400109Notes

Reaction equation

HRID 400109 reaction equation
Cl.Cl.O[C:4]1[N:16]=[CH:15][C:7]2[CH2:8][CH2:9][N:10]([CH2:13][CH3:14])[CH2:11][CH2:12][C:6]=2[CH:5]=1.P(Cl)(Cl)([Cl:19])=O>>[Cl:19][C:4]1[N:16]=[CH:15][C:7]2[CH2:8][CH2:9][N:10]([CH2:13][CH3:14])[CH2:11][CH2:12][C:6]=2[CH:5]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178462500HCID 178462500, compound

Product 1

HCID 189436073-Chloro-7-ethyl-6,7,8,9-tetrahydro-5H-pyrido[3,4-d]azepine

Procedure

Prepared from 3-hydroxy-7-ethyl-6,7,8,9-tetrahydro-5H-pyrido[3,4-d]azepine dihydrochloride by reaction with phosphorus oxychloride at 130° C.

Sources & evidence

ORD record
ord-0e26e0f32e74465d88d1bc9bae21568f
Source dataset
uspto-grants-1998_10
Patent number
US05827849

Reaction notes

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