HCID 22669967, compound → HCID 21841494, compound

HRID 400252Notes

Reaction equation

HRID 400252 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[CH:4][C:3]=1[C:12]1[CH:17]=[CH:16][C:15]([O:18]CC2C=CC=CC=2)=[CH:14][CH:13]=1>[Pd].C(OCC)(=O)C>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[CH:4][C:3]=1[C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=1

Participants

4

Reactant 1

HCID 22669967HCID 22669967, compound

Product 1

HCID 21841494HCID 21841494, compoundYield 99.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
20 °C

Procedure

The mixture of 286 mg of the product of Stage B, 91 mg of 9.5% palladium on charcoal and 20 ml of ethyl acetate was placed under a hydrogen atmosphere and the mixture was stirred at 20° C. for 24 hours. After filtration and concentration under reduced pressure, 211 mg of the expected product were obtained.

Workup

  1. filtrationAfter filtration and concentration under reduced pressure

Sources & evidence

ORD record
ord-f43cb7f94ba748b5bc98ff0f1142e932
Source dataset
uspto-grants-1998_10
Patent number
US05827887

Reaction notes

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