反应详情

To a cooled (0° C.) solution of tert-butylamine (42.9 mL, 410.6 mmol) in THF (840 mL) was added dropwise benzenesulfonyl chloride (26.2 mL, 205 mmol) and the reaction mixture was stirred at room temperature under an argon atmosphere for 6 h. The mixture was then filtered and the collected solid washed with THF. The filtrate was concentrated, redissolved in CH2Cl2 and washed with 0.1N HCl and H2O. The organic solution was dried and concentrated to afford the desired product (41.8 g, 95%).

1. filtrationThe mixture was then filtered
2. washthe collected solid washed with THF
3. concentrationThe filtrate was concentrated
4. dissolutionredissolved in CH2Cl2
5. washwashed with 0.1N HCl and H2O
6. customThe organic solution was dried
7. concentrationconcentrated