Triethylammonium hydroxide → HCID 86686051, compound

HRID 400453Notes

Reaction equation

HRID 400453 reaction equation
[OH-].C([NH+](CC)CC)C.[C:9]([NH:12][CH:13]1[C:17](=[O:18])[CH2:16][N:15]([C:19]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[O:20])[CH2:14]1)(=O)[CH3:10]>C1COCC1>[CH2:22]([O:21][C:19]([N:15]1[CH2:16][C:17]2[O:18][C:9]([CH3:10])=[N:12][C:13]=2[CH2:14]1)=[O:20])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

4

Reactant 2

HCID 21903323Triethylammonium hydroxideHCID 86686050Benzyl 3-acetamido-4-oxopyrrolidine-1-carboxylate

Product 1

HCID 86686051HCID 86686051, compoundYield 31.9%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
65 °C

Procedure

8.5 g methoxycarbonylsulfamoyl)triethylammoniumhydroxid was added to 4.7 g benzyl 3-acetamido-4-oxopyrrolidine-1-carboxylate in 180 mL THF. The reaction was stirred 1 h at 65° C. and evaporated. The residue was purified on silica gel (hexane/ethyl acetate:1/1) to give 1.4 g of the desired product.

Workup

  1. customevaporated
  2. customThe residue was purified on silica gel (hexane/ethyl acetate:1/1)

Sources & evidence

ORD record
ord-560ac167e85d483599e1a10467826ce3
Source dataset
uspto-grants-2014_06
Patent number
US08741892B2

Reaction notes

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