反应详情

6.7 g potassium carbonate was added to 7 g 5-oxo-azepane-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester in 50 mL DMF and stirred at RT. After 30 min 6.1 g ethyl bromoacetate was added and the reaction was stirred at RT over night. The reaction was diluted with water and extracted with ethyl acetate/hexane (1/1). The organic phase was washed with brine, dried and concentrated. The residue was purified by column chromatography on silica gel (15% ethyl acetate in hexane) to give 5.6 g of the desired product.

1. stirringthe reaction was stirred at RT over night
2. extractionextracted with ethyl acetate/hexane (1/1)
3. washThe organic phase was washed with brine
4. customdried
5. concentrationconcentrated
6. customThe residue was purified by column chromatography on silica gel (15% ethyl acetate in hexane)