反应详情

60 mL acetic acid was added to 16 g 4-carboxymethyl-5-oxo-azepane-1-carboxylic acid tert-butyl ester in 120 mL THF at 5° C. 14 mL hydrazine hydrate was added to the reaction and the mixture was refluxed over night. After completion of the reaction, volatiles were removed and the residue was basified with sodium carbonate and extracted with chloroform. The organic layer was dried and concentrated under reduced pressure to afford 11 g of the desired product

1. temperaturethe mixture was refluxed over night
2. customAfter completion of the reaction, volatiles
3. customwere removed
4. extractionextracted with chloroform
5. customThe organic layer was dried
6. concentrationconcentrated under reduced pressure