反应详情

3 g DDQ was added to 2.5 g 2-methyl-3-oxo-2,3,4,4a,5,6,8,9-octahydro-1,2,7-triaza-benzocycloheptene-7-carboxylic acid tert-butyl ester in 25 mL dioxane. The reaction was refluxed for 12 h. Then aqueous potassium carbonate solution was added and the mixture was extracted with chloroform. The organic layer was washed with brine. The crude product was purified by column chromatography on silica gel to yield 1.3 g of the desired product.

1. temperatureThe reaction was refluxed for 12 h
2. extractionthe mixture was extracted with chloroform
3. washThe organic layer was washed with brine
4. customThe crude product was purified by column chromatography on silica gel