反应详情

3.6 g 3,5-Bis-(4-fluoro-phenyl)-1H-pyrazole, 8.8 g K2CO3 and 1.34 mL 2-bromoacetic acid methyl ester were dissolved in 100 mL acetone and stirred over night under reflux. K2CO3 was filtered and the solvent was removed. The residue was purified by HPLC (method 1) to yield 2.6 g of the desired product.

1. temperatureunder reflux
2. filtrationK2CO3 was filtered
3. customthe solvent was removed
4. customThe residue was purified by HPLC (method 1)