Dimethylformamide dimethyl acetal → HCID 60026549, compound

HRID 400643Notes

Reaction equation

HRID 400643 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3](=[O:21])[CH2:4][C:5]([C:8]1[C:16]2[O:15][CH2:14][CH2:13][C:12]=2[CH:11]=[C:10]([S:17]([NH2:20])(=[O:19])=[O:18])[CH:9]=1)([CH3:7])[CH3:6].CO[CH:26](OC)[N:27]([CH3:29])[CH3:28]>ClCCl>[CH3:26][N:27]([CH3:29])/[CH:28]=[N:20]/[S:17]([C:10]1[CH:9]=[C:8]([C:5]([CH3:7])([CH3:6])[CH2:4][C:3](=[O:21])[C:2]([F:1])([F:22])[F:23])[C:16]2[O:15][CH2:14][CH2:13][C:12]=2[CH:11]=1)(=[O:19])=[O:18]

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 60026623HCID 60026623, compound

Product 1

HCID 60026549HCID 60026549, compoundYield 94.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 7-(4,4,4-trifluoro-1,1-dimethyl-3-oxobutyl)-2,3-dihydrobenzofuran-5-sulfonic acid amide (870 mg, 2.47 mmol) in 30 mL of dichloromethane was reacted with N,N-dimethylforamide dimethyl acetal (580 mg, 4.86 mmol). After 30 minutes, the mixture was concentrated in vacuo to dryness. The resulting solid was triturated with diethyl ether and collected to afford 950 mg of the title compound (94% yield).

Workup

  1. concentrationthe mixture was concentrated in vacuo to dryness
  2. customThe resulting solid was triturated with diethyl ether
  3. customcollected

Sources & evidence

ORD record
ord-f68f05ac55ac4eefa035e113a58d73f3
Source dataset
uspto-grants-2014_06
Patent number
US08741897B2

Reaction notes

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