反应详情

A mixture of 44c (60 mg, 0.28 mmol), 5e (105 mg, 0.36 mmol), HATU (159 mg, 0.42 mmol), Et3N (1 mL), and DMF (3 mL) was stirred at room temperature overnight, and then poured into water (10 mL). The mixture was extracted with EtOAc. The extracts were washed with brine, dried over Na2SO4 and concentrated. The residue was purified by flash column chromatography (silica gel, 7% MeOH/CH2Cl2) to give 98 mg of Cpd 913. MS m/z (M+H+) 450.0.

1. extractionThe mixture was extracted with EtOAc
2. washThe extracts were washed with brine
3. dry with materialdried over Na2SO4
4. concentrationconcentrated
5. customThe residue was purified by flash column chromatography (silica gel, 7% MeOH/CH2Cl2)
6. customto give 98 mg of Cpd 913