反应详情

To a suspension of methyl 4-amino-3-chlorobenzoate (33 g, 146 mmol, 1 eq) in a 1:1 mixture of concentrated HCl and water (140 ml) cooling in an ice/MeOH bath was added a solution of sodium nitrite (11.1 g, 160 mmol, 1.1 eq) in warm water (20 ml) dropwise, ensuring that the reaction temperature was maintained below 5° C. The mixture was filtered through a pad of Celite and the solids washed with water. The resulting filtrate was added portionwise to a mixture of sulphur dioxide (47 g, 729 mmol, 5 eq) and copper (I) chloride (catalytic) in AcOH, maintaining the reaction temperature below 10° C. The reaction mixture was extracted into DCM (600 ml), washed with water (600 ml), dried over sodium sulphate, filtered and the solvent evaporated in vacuo. The residue was redissolved in DCM, washed with saturated sodium hydrogen carbonate, dried over sodium sulphate, filtered and evaporated in vacuo. The crude material was purified by column chromatography eluting with 0-15% ethyl acetate:hexane then triturated with hexane to yield the title compound (19.6 g, 73.6 mmol, 50%).

1. temperaturecooling in an ice/MeOH bath
2. temperaturewas maintained below 5° C
3. filtrationThe mixture was filtered through a pad of Celite
4. washthe solids washed with water
5. temperaturemaintaining the reaction temperature below 10° C
6. extractionThe reaction mixture was extracted into DCM (600 ml)
7. washwashed with water (600 ml)
8. dry with materialdried over sodium sulphate
9. filtrationfiltered
10. customthe solvent evaporated in vacuo
11. dissolutionThe residue was redissolved in DCM
12. washwashed with saturated sodium hydrogen carbonate
13. dry with materialdried over sodium sulphate
14. filtrationfiltered
15. customevaporated in vacuo
16. customThe crude material was purified by column chromatography
17. washeluting with 0-15% ethyl acetate
18. customhexane then triturated with hexane