反应详情

温度

5 °C

Rasagiline base (81 g, 0.47 moles) was dissolved in IPA (810 ml) under stirring and the obtained solution was cooled to 5° C. A solution of methanesulfonic acid (0.49 moles, 47.7 g) in IPA (95 ml) was added dropwise to the above cooled solution. After complete addition, the mixture was stirred for 30 min at 5-10° C. to get the solid which was filtered and dried to get (105 g, 83%) of Rasagiline mesylate.

1. additionAfter complete addition
2. stirringthe mixture was stirred for 30 min at 5-10° C.
3. customto get the solid which
4. filtrationwas filtered
5. customdried