反应详情

To a mixture of 2.87 g of iron, 10 ml of acetic acid and 10 ml of water was added a mixture of 3.84 g of 3-nitro-5-(trifluoromethyl)pyridine-2-thiol and 10 ml of ethyl acetate at 70° C. over a period of 10 minutes. The reaction mixture was cooled down to room temperature, then, to the reaction mixture was added water, and the resultant mixture was extracted with ethyl acetate twice. The combined organic layers were washed with water and saturated saline, dried over magnesium sulfate, then, concentrated under reduced pressure to obtain 3.1 g of 3-amino-5-(trifluoromethyl)pyridine-2-thiol.

1. additionwas added
2. extractionthe resultant mixture was extracted with ethyl acetate twice
3. washThe combined organic layers were washed with water and saturated saline
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated under reduced pressure