反应详情

To a solution of the compound (0.050 g, 0.13 mmol) of Example 1 in ethanol (1.0 mL), 50% potassium hydroxide solution (0.5 mL, 0.13 mmol) was added at ambient temperature. The mixture was refluxed for 1 h. Cooled to ambient temperature, the precipitate was collected by filtration, washed with ethanol. The crude material was dissolved in water (0.5 mL) and tetrahydrofuran (0.5 mL), then 2M hydrochloric acid (0.023 mL, 0.046 mmol) was added and the mixture was stirred for 30 min. The precipitate was collected by filtration, washed with water and diethyl ether then dried to afford the titled compound (0.012 g, y. 26%).

1. temperatureThe mixture was refluxed for 1 h
2. filtrationthe precipitate was collected by filtration
3. washwashed with ethanol
4. dissolutionThe crude material was dissolved in water (0.5 mL)
5. filtrationThe precipitate was collected by filtration
6. washwashed with water and diethyl ether
7. customthen dried