HCID 178469744, compound → HCID 178516488, compound

HRID 402725Notes

Reaction equation

HRID 402725 reaction equation
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([CH:10]=[C:11]2[O:15][C:14]([NH:16][CH2:17][C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)=[C:13](C(OCC)=O)[C:12]2=[O:30])=[CH:2]1>CN(C)C(=O)C.O>[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([CH:10]=[C:11]2[C:12](=[O:30])[CH:13]=[C:14]([NH:16][CH2:17][C:18]3[CH:19]=[CH:20][C:21]([F:24])=[CH:22][CH:23]=3)[O:15]2)=[CH:2]1

Participants

4

Reactant 1

HCID 178469744HCID 178469744, compound

Product 1

HCID 178516488HCID 178516488, compoundYield 9%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 31374DimethylacetamideSolvent

Procedure

A solution of the compound (0.10 g, 0.31 mmol) of Example 45 in N,N-dimethylacetamide (3.0 mL) was refluxed for 7 h. Cooled to ambient temperature, the reaction mixture was diluted with water and the precipitate was collected by filtration. The solid was washed with water and diethyl ether then dried to afford the titled compound as solid (0.0070 g, y. 9%).

Workup

  1. filtrationthe precipitate was collected by filtration
  2. washThe solid was washed with water and diethyl ether
  3. customthen dried

Sources & evidence

ORD record
ord-fed1b5468f3e4ba8860bce620c58129d
Source dataset
uspto-grants-2014_06
Patent number
US08742113B2

Reaction notes

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