HCID 178469525, compound → HCID 178516400, compound

HRID 402727Notes

Reaction equation

HRID 402727 reaction equation
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([CH:10]=[C:11]2[O:15][C:14]([NH:16][CH:17]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)=[C:13](C(OCC)=O)[C:12]2=[O:29])=[CH:2]1>CN(C)C=O>[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([CH:10]=[C:11]2[C:12](=[O:29])[CH:13]=[C:14]([NH:16][CH:17]3[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]3)[O:15]2)=[CH:2]1

Participants

3

Reactant 1

HCID 178469525HCID 178469525, compound

Product 1

HCID 178516400HCID 178516400, compoundYield 12.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of the compound (0.040 g, 0.10 mmol) of Example 59 in N,N-dimethylformamide (2.0 mL) was refluxed for 8 h. Cooled to ambient temperature, the reaction mixture was purified by preparative HPLC to afford the titled compound as solid (0.0040 g, y. 12%).

Workup

  1. customthe reaction mixture was purified by preparative HPLC

Sources & evidence

ORD record
ord-f4d0ffc5ba724dbe999d628574d2fb1c
Source dataset
uspto-grants-2014_06
Patent number
US08742113B2

Reaction notes

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