HCID 178469775, compound → HCID 178456796, compound

HRID 402728Notes

Reaction equation

HRID 402728 reaction equation
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([CH:10]=[C:11]2[O:15][C:14]([NH:16][CH:17]([CH3:19])[CH3:18])=[C:13](C(OCC)=O)[C:12]2=[O:25])=[CH:2]1>CN(C)C(=O)C.O>[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([CH:10]=[C:11]2[C:12](=[O:25])[CH:13]=[C:14]([NH:16][CH:17]([CH3:19])[CH3:18])[O:15]2)=[CH:2]1

Participants

4

Reactant 1

HCID 178469775HCID 178469775, compound

Product 1

HCID 178456796HCID 178456796, compoundYield 13%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 31374DimethylacetamideSolvent

Procedure

A solution of the compound (0.15 g, 0.43 mmol) of Example 56 in N,N-dimethylacetamide (1.5 mL) was refluxed for 12 h. Cooled to ambient temperature, the reaction mixture was diluted with water and the precipitate was collected by filtration. The solid was washed with diethyl ether then dried to afford the titled compound as solid (0.015 g, y. 12%).

Workup

  1. filtrationthe precipitate was collected by filtration
  2. washThe solid was washed with diethyl ether
  3. customthen dried

Sources & evidence

ORD record
ord-935fdab9fd1d43ab93d665a57720b965
Source dataset
uspto-grants-2014_06
Patent number
US08742113B2

Reaction notes

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