反应详情

A solution of 2,4-dibromo-6-methylphenol (2.0 g, 7.5 mmol), 3-bromo-2-methylprop-1-ene (1.5 g, 11.3 mmol), K2CO3 (3.12 g, 22.6 mmol) in DMF (15 mL) was heated at 70° C. 2 hours. The reaction was then cooled to room temperature and was diluted with water and hexanes. The layers were separated and the organic layer was dried over sodium sulfate, filtered and concentrated. The residue was purified on a silica gel column eluting with a gradient of 0-10% EtOAc/hexanes to give the title intermediate (1.05 g) as colorless liquid.

1. custom2 hours
2. customThe layers were separated
3. dry with materialthe organic layer was dried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. customThe residue was purified on a silica gel column
7. washeluting with a gradient of 0-10% EtOAc/hexanes