反应详情

A mixture of the iodo amino acid 23 (0.86 mmol), camphorsulfonic acid (0.17 mmol), paraformaldehyde (1.29 mmol) and benzene (10 mL) was refluxed for 2 h. The mixture was diluted with ethyl acetate and was washed with 5% aqueous sodium bicarbonate solution. The organic phase was dried with anhydrous sodium sulfate, filtered and purified by silica gel column chromatography using 40% EtOAc/Hexane mixture as eluent to obtain pure oxazolidinone product 24 (N-(tert-butoxycarbonyl)-1,3-oxazolidin-5-one derivative) as an oil in 35% yield.

1. temperaturewas refluxed for 2 h
2. washwas washed with 5% aqueous sodium bicarbonate solution
3. dry with materialThe organic phase was dried with anhydrous sodium sulfate
4. filtrationfiltered
5. custompurified by silica gel column chromatography