Hydrochloric Acid → HCID 46829926, compound

HRID 403018Notes

Reaction equation

HRID 403018 reaction equation
C(OC([NH:8][CH2:9][CH2:10][C:11]([O:13][CH2:14][C@@H:15]([O:49][C:50](=[O:61])[CH2:51][CH2:52][NH:53]C(OC(C)(C)C)=O)[CH2:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[C:29]([C:30]#[N:31])=[C:28]([S:32][CH2:33][C:34]3[N:35]=[C:36]([C:39]4[CH:44]=[CH:43][C:42]([Cl:45])=[CH:41][CH:40]=4)[O:37][CH:38]=3)[N:27]=[C:26]([NH2:46])[C:25]=2[C:47]#[N:48])=[CH:20][CH:19]=1)=[O:12])=O)(C)(C)C.[ClH:62]>ClCCl.C(OCC)C>[ClH:45].[ClH:62].[NH2:8][CH2:9][CH2:10][C:11]([O:13][CH2:14][C@@H:15]([O:49][C:50](=[O:61])[CH2:51][CH2:52][NH2:53])[CH2:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[C:29]([C:30]#[N:31])=[C:28]([S:32][CH2:33][C:34]3[N:35]=[C:36]([C:39]4[CH:40]=[CH:41][C:42]([Cl:45])=[CH:43][CH:44]=4)[O:37][CH:38]=3)[N:27]=[C:26]([NH2:46])[C:25]=2[C:47]#[N:48])=[CH:20][CH:19]=1)=[O:12]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67400529HCID 67400529, compound

Product 1

HCID 46829926HCID 46829926, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

An amount of 123 mg (0.140 mmol) of the compound from example 28A was introduced in 2 ml of dichloromethane and admixed with 1.4 ml (2.807 mmol) of a 2M solution of hydrogen chloride gas in diethyl ether. After 1 hour of stirring, the precipitated solid was isolated by filtration, washed with dichloromethane and diethyl ether and dried under reduced pressure. This gave 79 mg (75% of theory) of the target compound.

Workup

  1. customthe precipitated solid was isolated by filtration
  2. washwashed with dichloromethane and diethyl ether
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-9a052f857cbd4d58b25972c8eac161f8
Source dataset
uspto-grants-2014_06
Patent number
US08741834B2

Reaction notes

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