反应详情

温度

110 °C

A mixture of compound 22m (150 mg, 0.532 mmol) and CuI (60 mg, 0.32 mmol) in DMF (1.5 mL) was heated at 110° C. for 5 h and them cooled to room temperature. The reaction was quenched with water and extracted with EtOAc. The organic layer was concentrated and purified by flash column chromatography (silica gel, 15% EtOAc/hexanes) to give compound 22n.

1. temperaturethem cooled to room temperature
2. customThe reaction was quenched with water
3. extractionextracted with EtOAc
4. concentrationThe organic layer was concentrated
5. custompurified by flash column chromatography (silica gel, 15% EtOAc/hexanes)