1-Benzyl-4-(1-methyl-1H-tetrazol-5-YL)piperidine → 4-(1-methyl-1H-tetrazol-5-yl)-piperidine

HRID 403509Notes

Reaction equation

HRID 403509 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:18]([CH3:19])[N:17]=[N:16][N:15]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[OH-].[OH-].[Pd+2]>[CH3:19][N:18]1[C:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[N:15][N:16]=[N:17]1

Participants

4

Reactant 1

HCID 683791341-Benzyl-4-(1-methyl-1H-tetrazol-5-YL)piperidine

Product 1

HCID 666923984-(1-methyl-1H-tetrazol-5-yl)-piperidine

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

Pd(OH)2 (20% on C, 30 mg) was added to a solution of 1-benzyl-4-(1-methyl-1H-tetrazol-5-yl)-piperidine (37) (150 mg, 0.58 mmol) in 15 ml of ethanol and the mixture was hydrogenated at 4-5 bar H2 at 50° C. for 16 h. The catalyst was filtered off and the solvent was evaporated to give 38 as a colorless solid.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-b7e49b278c2e48508dee327132097926
Source dataset
uspto-grants-2014_06
Patent number
US08748435B2

Reaction notes

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