反应详情

A mixture of the compound of example 4 (1.54 g, 0.0044 mol) and L-valine methyl ester hydrochloride (0.813 g, 0.0048 mol) was taken in toluene (30 mL) in a round bottom flask. To this reaction mixture, triethyl amine (0.98 g, 0.0097 mol) was added and refluxed for 3-4 h. After completion of the reaction, the reaction mixture was diluted with ethyl acetate and washed with water and brine, dried over anhydrous sodium sulfate and concentrated to obtain an oily material, which was purified by column chromatography (silicagel, 30% ethyl acetate in petroleum ether).

1. temperaturerefluxed for 3-4 h
2. customAfter completion of the reaction
3. washwashed with water and brine
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated
6. customto obtain an oily material, which
7. customwas purified by column chromatography (silicagel, 30% ethyl acetate in petroleum ether)