反应详情

Dissolved (E)-tert-butyl (6-((hydroxyimino)methyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methylcarbamate (200 mg, 0.684 mmol) in 25 mL of DMF and added 1-chloropyrrolidine-2,5-dione (95.9 mg, 0.718 mmol). Let stir at rt for 2 h. Poured reaction mixture onto water (20 mL) and extracted with ether (3×20 mL). Washed organics with water (2×20 mL), brine (1×20 ml), dried over sodium sulfate, filtered and concentrated. Title compound used without further purification (220 mg, 97% yield).

1. additionPoured
2. customreaction mixture onto water (20 mL)
3. extractionextracted with ether (3×20 mL)
4. dry with materialWashed organics with water (2×20 mL), brine (1×20 ml), dried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated
7. customTitle compound used without further purification (220 mg, 97% yield)